Advanced Muscle Plus is a dietary supplement from Advanced Bionutritionals, marketed primarily for adults over 40 (and older, like those in their 60s–80s) to combat age-related muscle loss (sarcopenia), boost muscle protein synthesis, improve strength, recovery, energy, balance, and posture. It targets the idea that the mTOR pathway (a key “switch” for muscle growth) becomes less responsive with age, making it harder to build or maintain muscle despite diet and exercise.
Table of Contents
Key Ingredients and Claims
The formula highlights two main patented/featured compounds:
- Peptide DL185™ (Dileucine): A dipeptide form of leucine (two leucine molecules bonded). The product claims it boosts muscle protein synthesis by up to 159% and leads to significant strength gains (e.g., +133 lbs on leg press in a 10-week study, nearly 3x placebo).
- MyHMB®: A form of HMB (β-hydroxy-β-methylbutyrate), a leucine metabolite. It claims to reduce age-related muscle loss by 57%, preserve muscle during inactivity, and support growth.
Other details include taking it post-workout or with a meal, a 90-day money-back guarantee (even empty bottles, minus shipping), and endorsement by Dr. Greg Eckel (a naturopathic physician, compensated by the company).
The provided page shows 6 positive customer reviews (5.0/5 average), mostly from older users reporting better balance, strength, stamina, muscle regain (e.g., ~4 lbs lean mass in 3 months for a 68-year-old), and workout performance (e.g., a 75-year-old keeping up with 40-year-olds). These are verified and include disclaimers that results vary and aren’t typical.
Summary Table: Key Aspects
| Aspect | Details | Evidence/Notes |
|---|---|---|
| Main Ingredients | Dileucine (DL185™) 2g, MyHMB® 1.5g | Patented, research-backed forms |
| Primary Mechanism | Activates mTOR for MPS (Dileucine); Reduces breakdown (MyHMB) | Boosts building + protects muscle |
| Key Benefits | Muscle growth, strength, recovery, energy, balance, anti-aging effects | Supported by ingredient studies |
| Best For | Adults 40+ with sarcopenia concerns; those doing resistance training | Complements diet/exercise |
| User Ratings | Official: 5/5 (small sample); Amazon: 3.8/5; Trustpilot (brand): 4.0/5 | Positive overall, varies by source |
| Potential Drawbacks | Pricey (~$67–80/bottle); Results take time; Not FDA-evaluated for claims | Consult doctor; pair with protein/training |
| Guarantee | 90-day full refund (even empty bottles, minus shipping) | Low-risk trial |
What Independent Sources Say
- Customer Reviews Elsewhere: On sites like Amazon, it has a moderate rating (around 3.8/5 from a smaller number of reviews). Trustpilot for Advanced Bionutritionals overall is about 4.0/5 (based on 500+ reviews across products), with praise for effectiveness in health improvements (e.g., energy, bone density), though some complaints mention aggressive upsell tactics during checkout. No widespread red flags for this specific product, but third-party sites often show high ratings (4.8–4.9/5) that appear promotional or aggregated.
- Scientific Backing for Ingredients:
- Dileucine (DL185™) has promising peer-reviewed studies (e.g., in PLOS ONE and PubMed). One double-blind trial showed it outperforms standard leucine in stimulating muscle protein synthesis (by ~60% in some measures) and leads to better lower-body strength gains (+144–189% vs. placebo in trained individuals over 10 weeks). It’s researched for muscle building in younger and resistance-trained people, with potential carryover to older adults fighting sarcopenia.
- MyHMB®/HMB has stronger evidence for older adults: Multiple meta-analyses and reviews (e.g., in Journal of Cachexia, Sarcopenia and Muscle) show it helps preserve muscle mass, improve strength/function, reduce loss during inactivity/bedrest, and support recovery. Benefits are seen at ~3g/day over 12+ weeks, often in combination with exercise (though some gains occur without intense training).
- Overall Product Evidence: No large-scale independent trials on the exact Advanced Muscle Plus formula exist in the sources. Claims draw from ingredient studies, which are legitimate but often in specific populations (e.g., younger trained men for dileucine; older/inactive for HMB). Results vary widely based on diet, exercise, age, and consistency—supplements like this work best alongside resistance training and protein intake.
- Customer Reviews
- The official site features 6 glowing 5-star reviews (from users aged 60s–84) reporting better balance, regained muscle mass (e.g., ~4 lbs lean mass in 3 months for a 68-year-old), increased strength/stamina (e.g., a 75-year-old keeping up with 40-year-olds), and enhanced workout performance.
- Broader online feedback (as of early 2026):
- Amazon — 3.8/5 stars from ~37 reviews. Mixed but mostly positive; some users over 65 note benefits, with comments like “pricey but impressive” or questions about peptide efficacy. A few neutral/lower ratings mention slower results.
- Company-wide (Advanced Bionutritionals on Trustpilot) — 4.0/5 from 535+ reviews across products. Customers praise health impacts (e.g., energy, bone density, muscle support), quality, and effectiveness; long-term users often highlight tangible improvements.
- Aggregated/promotional sites claim high ratings (e.g., 4.8–4.9/5 from hundreds to thousands), with users noting firmer muscles, faster recovery, and strength gains — but these may include biased or early feedback.
- No major red flags like widespread complaints or scams; some note it’s pricey and works best with exercise.
- Results vary — individual experiences depend on age, diet, activity, and consistency. Testimonials aren’t typical guarantees.
Potential Drawbacks and Considerations
- Not a Miracle: It’s not a replacement for exercise or diet. Some users note results take time (weeks/months) and require consistency. No major side effects reported, but consult a doctor if you have conditions (standard disclaimer: not FDA-evaluated to treat/prevent disease).
- Marketing Style: The sales page uses strong claims, testimonials, and urgency (e.g., “Build Muscle or it’s Free”). Some reviews of the company mention pushy sales funnels. No evidence of it being a outright scam—it’s sold legitimately (e.g., Amazon, Walmart, official site), with a refund policy.
- No Major Complaints/Scams Found: Searches for scams or widespread issues turned up nothing specific; general supplement industry warnings apply (e.g., exaggerated claims).
In summary, Advanced Muscle Plus appears legitimate with science-backed ingredients that could help older adults maintain or build muscle, especially with resistance training. The provided reviews align with broader positive feedback for energy, strength, and recovery in aging users. If you’re considering it (e.g., for sarcopenia concerns), the 90-day guarantee reduces risk—start with one bottle and track progress. Always pair with strength exercises, adequate protein, and medical advice for best results. Results aren’t guaranteed and vary.
